Great quote from James K.A. Smith:
At its heart, the Kuyperian tradition has emphasized the lordship of Christ over all things and hence affirmed creation and culture as realms of God's redemptive in-breaking grace (Col. 1:15–20). Rejecting the functional Gnosticisms of fundamentalism and otherworldly pietism, neo-Calvinists have emphasized a "transformative" project—or at least the importance of cultural labor that is restorative and redemptive—undertaken by a people fueled by grace and informed by revelation’s claims about how things ought to be. Redemption, then, is about bodies as much as souls and is about social bodies as much as individuals. In Christ, our creating and redeeming God effects a redemption that is nothing short of cosmic and nothing less than cultural. The wonderworking power released by the resurrection redeems us from punishment but also retools the arts to the glory of God; the ascended Christ grants his Spirit to empower us to overcome sin, but the same Spirit also equips us to probe into the nooks and crannies of cell biology, trying to undo the curse of disease. In short, the Great Commission is the announcement of the Good News that Christ has made it possible for us to take up once again humanity's cultural mandate. God's grace is as wide as his good creation, and he gathers us as a people to take up our creational task of forming and transforming creation for his glory.
"Reforming Public Theology: Two Kingdoms, or Two Cities?" Calvin Theological Journal 47 (2012): 122-137, linked from James K.A. Smith's blog.